Scientific Program

Scientific Program



Monday, September 12, 2016

h. 13.00-18.00  Registration and Poster set up

h. 14.30-16.30  Workshop “Role of Vitamin D in Skin Cancer Risk and Prognosis

h. 14.00-17.00 ESPCR Council Meeting

h. 17.00-17.15 Opening Remarks

Session 1: Development and Migration of Melanocytes – Chair: Eirikur Steingrimsson
(Dept. of Biochemistry and Molecular Biology, Reykjavik, Iceland)

h. 17.15-17.45 Lukas Sommer

Dept. of Oncology, University Hospital Zurich, Zurich, Switzerland
“Yy1 Is a Central Regulator of Metabolism and Growth in Neural Crest Stem Cells and Melanoma”

h. 17.45-18.00 Corinna Köhler
Lab. for Molecular Cancer Biology, Center for the Biology of disease, VIB, Leuven, Belgium
“Long-lived Fully Differentiated Melanocytes can Serve as Cellular Origin of Cutaneous Melanoma”

h. 18.00-18.15 Yusuke Nagao
Biosci. Biotech. Ctr., Nagoya Univ., Japan; Dept. of Biol. & Biochem., Univ. of Bath, UK
“Sox5 Modulates Sox10-mediated Pigment Cell Fate Specification in Medaka amd Zebrafish”

h. 18.15-18.30 Kyriakos Orfanidis
Dept. of Dermatology and Venerology, and Dept. of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
“Evaluation of TUBB3 as a Novel Diagnostic Marker to Distinguish Nevi from Melanoma”

h. 18.3019.00 Margret H. Ogmundsdottir
School of Health Sciences – Faculty of Medicine, Reykjavik, Iceland
“The Transcriptional Regulation of Autophagy in Melanoma”

h. 19.30-21.00 Welcome Aperitif

Tuesday, September 13, 2016

Session 2: Pigmentation Disorders – Chair: Mauro Picardo
(San Gallicano Dermatologic Institute, Rome, Italy)

h. 09.00-09.30 Julien Seneschal
INSERM U1035, Université de Bordeaux, Bordeaux, France
“New Insights on Innate and Adaptative Immune Response in Vitiligo”

h. 09.30-09.45 Doreen Schwochow-Thalmann
Dept. of Animal Breeding anf Genetics, Swedish University of Agricultural Sciences, Sweden; GABI, INRA, AgroParisTech, Universitė Paris-Saclay, Jouy-en-Josas, France
” Towards Understanding the Molecular Basis of Pigment Pattern Formation in Birds”

h. 09.45-10.15 Maria Vittoria Schiaffino
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
“Role of the Master Lysosomal Regulator TFEB in the Pathogenesis of Ocular Albinism”

h. 10.15-10.30 Marta Abrisqueta González
Dept. of Biochemistry, Molecular Biology and Immunology, University of Murcia, Spain, and Instituto Murciano de Investigación Biomédica (IMIB)
“Human Melanocortin 1 Receptor (MC1R)-dependent Post-translational Modification of β-Arrestins (ARRBs)”

h. 10.30-10.45 Ian J. Jackson
University of Edinburgh, Edinburgh, UK
“The Genetics and Genomics of Human Hair Colour Variation”

h. 10.45-11.10 Coffee break

Session 3: Melanins and Melanogenesis: Mechanisms of Control and Applications – Chair: Alessandra Napolitano
(Department of Chemical Sciences, University of Naples Federico II, Naples, Italy)

h. 11.10-11.40 Shosuke Ito
Dept. of Chemistry, Fujita Health University, Nagoya, Japan
“Biochemical Mechanism of Rhododendrol-induced Leukoderma”

h. 11.40-11.55 Patrick Bogdanowicz
Dermo Cosmetic Center, Toulouse, France
“Preclinical and Clinical Efficacy of a Dermo-Cosmetic Skin Lightening Cream in Women Suffering from Melasma”

h. 11.55-12.10 Miguel C. Seabra
CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
“Melanin Processing by Keratinocytes After Transfer”

h. 12.10-12.25 Lucia Panzella
Dept. of Chemical Sciences, University of Naples “Federico II”, Naples, Italy
“The Role of Carboxyl Groups in Eumelanin and Pheomelanin Properties”

h. 12.25-12.40 Tadeusz Sarna
Dept. of Biophysics, Jagiellonian University, Krakow, Poland
“Photogeneration and Quenching of Singlet Oxygen and Superoxide Anion by Synthetic Eumelanins and Pheomelanins”

h. 12.40-13.45 Lunch

h. 12.40-13.45 Round table: “Science is Not Gender Neutral, Fortunately”
Chair: Luisa Lanfrancone (European Institute of Oncology, IEO, Milan, Italy)
Discussant: Susanna Chiocca, Marie-Dominique Galibert, Sara Gandini, Marisol Soengas

h. 14.00-15.00 Keynote Lecture: Andrea Ballabio
Telethon Institute of Genetics and Medicine, TIGEM, Naples, Italy
“The Awesome Lysosome”

h. 15.00-15.20 Coffee break

Session 4: Molecular Epidemiology – Chair: Sara Gandini
(European Institute of Oncology, IEO, Milan, Italy)

h. 15.20-15.50 Mathieu Boniol
International Prevention Research Institute, Lyon, France
“Melanoma Mortality Worldwide, Toward a Decreasing Burden in the Next Decades”

h. 15.50-16.05 Roberta Colucci
Dept. of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy
“Association of Vitamin D Status with Clinical Features and Repigmentation in Vitiligo Patients: Preliminary Results from an Observational Study”

h. 16.05-16.20 Chiara Martinoli
Melanoma Medical Oncology Unit, European Institute of Oncology, Milan, Italy
“Prognostic Relevance of Baseline Hematological Profiles in Melanoma Patients”

h. 16.20-16.50 Susana Puig
Dermatology Department, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
“Clinical Implications of Genetics of Melanoma”

Night at disposal for participants

Wednesday, September 14, 2016

Session 5: Melanocytes and Melanoma Molecular Pathways – Chair: Marie-Dominique Galibert
(IGDR, University of Rennes, Rennes, France)

h. 09.00-09.30 Laura Machesky

Cancer Research UK Beatson Institute, Glasgow, UK
“RhoGTPases Control Melanoblast Migration”

h. 09.30-09.45 Vittoria Maresca
San Gallicano Dermatologic Institute, Rome, Italy
“Role of A-MSH in the Control of Proliferation in Melanocytes and Melanoma Cells”

h. 09.45-10.00 Gian Marco De Donatis
INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), team 12, Nice, France
“NIK Inhibition Potentiates Anti-PD1 Treatment by Inducing IFN-y Release by Cancer Cells”

h. 10.00-10.30 Yardena Samuels

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
“RASA2 is a Novel Tumor Suppressor in Melanoma”

h. 10.30-10.50 Coffee break

Session 6: Melanocytes and Melanoma Molecular Pathways (continued) – Chair: Colin Goding
(Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK)

h. 10.50-11.20 Daniel Peeper
Department of Molecular Oncology, NKI, Amsterdam, The Netherlands
“Systematic Genetic Perturbations to Reveal Melanoma Vulnerabilities”

h. 11.20-11.35 Marie-Dominique Galibert
CNRS UMR 6290, IGDR, Université de Rennes; CHU Rennes, Laboratoire de Génomique Médicale, Rennes, France
“Tailored Small Oligonucleotides Abolish MiRNA Sequestration and Restore MicroRNA Tumour Suppressor Activity”

h. 11.35-11.50 Marine Melixetian
Dept. of Experimental Oncology, European Institute of Oncology, Milan, Italy
“Loss of Long Non Coding, RNA TINCR Promotes Melanoma Growth and Metastasis Formation by Inducing a Switch to an Invasive Phenotype”

h. 11.50-12.20 Ze’ev Ronai

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA

“A Transcriptionally Inactive ATF2 Variant Drives Melanogenesis”

h. 12.20-13.00 Lunch

h. 13.00-14.45 Poster session

h. 14.45-15.30 Flash talks – Chair: Yardena Samuels (Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel)

h. 14.45-14.50 Jacques Rouanet
UMR990 INSERM UdA Clermont-Ferrand; Dermatology Dept., CHU Estaing Clermont-Ferrand, France
“Melanoma Targeted Radionuclide Therapy with Melanin-Ligands: Molecular Mechanisms and Potentialisation”

h. 14.50-14.55 Ahmad Najem
LOCE, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
“Opposite Roles for MITF and P53 in the Resistance of Mutant NRAS Melanoma to MEK Inhibition”

h. 14.55-15.00 Ilse Hurbain
Institut Curie, PSL Research University, CNRS, UMR 144,; Sorbonne Université, Paris, France
“A Systematic Analysis of Melanosome Structure and Distribution in Different Skin Color Phenotypes: Identification of Melanocore Clusters as Lysosome Related Organelles”

h. 15.00-15.05 Seung Hyun Bang
Dept. of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
“A Novel Ion Channel Activator, CyPPA Inhibits Melanogenesis via the GSK3β/β-catenin Pathway”

h. 15.05-15.10 Justine Leclerc
“Oncogenic MITFE318K Promotes Senescence Delay and Melanoma Progression”

h. 15.10-15.15 Josue Ballesteros
Dept. of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
“MITF, TFEB and TFE3 in Melanoma – Regulation and Interaction”

h. 15.15-15.20 Lluís Montoliu
Centro Nacional de Biotecnología (CNB-CSIS) y Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER-ISCIII), Madrid, Spain
“New Mouse Models of Albinism Generated with CRISP-Cas9 Technology”

h. 15.20-15.30 Open Discussion

Interactive Session with Researchers and Clinicians
Melanoma Models: What Is Needed to Move from Bench to Bedside?
Chair: Sara Gandini & Luisa Lanfrancone (European Institute of Oncology, IEO, Milan, Italy)

h. 15.30-15.50 Lionel Larue
Institut Curie, Orsay, France
“Relevance of In Vivo and In Vitro Models for Melanoma”

h. 15.50-16.10 Pier Francesco Ferrucci
European Institute of Oncology, IEO, Milan, Italy
“Immunotherapy and New Targets in the Treatment of Advanced Melanoma”

h. 16.10-16.30 Daniela Massi
Division of Pathological Anatomy, University of Florence, Florence, Italy
“Tissue Biomarkers’ Development”

h. 16.30-17.00 Open discussion

h. 17.00-17.20 Coffee break

Session 7: Cell Metabolism Dysregulation in Melanoma – Chair: Corine Bertolotto
(INSERM U1065, Université de Nice Sophia-Antipolis, Nice, France)

h. 17.20-17.50 Colin Goding

Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK
“An Evolutionarily Conserved Driver of Melanoma Invasiveness”

h. 17.50-18.05 Stefania Guida
Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy
“Metabolic Reprogramming in Melanoma: the Role of Peif2alpha”

h. 18.05-18.20 Stéphane Rocchi
INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Equipe Biologie et Pathologie des cellules mélanocytaire : de la pigmentation cutanée au mélanome, Nice;  Université de Nice Sophia Antipolis, UFR de Médecine, Nice; Service de Dermatologie, Hôpital Archet II, CHU Nice, France
“New Compounds Triggering Endoplasmic Reticulum Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance”

h. 18.20-18.50 Jean Christophe Marine
Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
“Integrative and Comparative Genomics Analyses Identify Genetic and Epigenetic Drivers of Melanoma”

h. 20.30 Social Dinner

Thursday, September 15, 2016

Session 8: Melanoma Microenvironment and the Role of Inflammation – Chair: Lionel Larue
(Institut Curie, Orsay, France)

h. 9.00-9.30 Thomas Tueting

Department of Dermatology University Hospital Magdeburg, Germany

”The Role of Neutrophils in Melanoma Pathogenesis and Resistance to Immunotherapy”

h. 9.30-9.45 Thomas Rouillé
Institut National de la Santé et de la Recherche Médicale (INSERM), U938, Saint-Antoine Research Center,  Paris; Université Pierre et Marie Curie-Paris VI,  Paris, France
“Varying Proliferative and Clonogenic Potential in NRAS-mutated Congenital Melanocytic Nevi According to Size”

h. 9.45-10.00 Petra Wäster
Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping, Sweden
“The Relationship Between UV Induced Lysosomal Exocytosis and Melanosome Transfer in Melanocytes”

h. 10.00-10.20 Coffee break

h. 10.20-10.50 Marisol Soengas

Molecular Pathology Programme, CNIO, Madrid, Spain
“Imaging and Targeting Pre-metastatic Niches in Melanoma”

h. 10.50-11.50 Fritz Anders Memorial Lecture: Richard Marais

Cancer Research UK Manchester Institute, Manchester, UK
“Precision Medicine for Melanoma”

h. 11.50-12.50  ESPCR Assembly

h. 13.00-14.00 Light lunch

Session 9: Highlights from the Other Pigment Cell Societies – Chair: Lluis Montoliu
(Department of Molecular and Cellular Biology, National Centre for Biotechnology, Madrid, Spain)

h. 14.00-14.15 Kyoung-Chan Park

Dept. of Dermatology, Seoul National University Bundang Hospital/ASPCR, Seongnam, Korea
“New Aspects of Melasma Treatment in Asians”

h. 14.15-14.30 Boon Kee Goh

Mount Elizabeth Medical Centre/ASPCR, Singapore, Singapore
“When a Leukoderma is not Vitiligo”

h. 14.30-14.45 Kazumasa Wakamatsu

Dept. of Chemistry, Fujita Health University, School of Health Science Toyoake/JSPCR, Aichi, Japan

“The Metabolic Fate of Ortho-quinones Derived from Catecholamine Metabolites”

h. 14.45-15.00 Caroline Le Poole

Dept. of Microbiology and Immunology, Loyola University Chicago/PASPCR, Chicago, USA

 “Testing HSP70iQ435A Treatment for Vitiligo in Large Animals”

Closing remarks

End of the meeting

h. 15.30-17.30 IFPCS Council Meeting